L2C Guinea Pig Lymphatic Leukemia: A "B" Cell Leukemia

L2C Guinea pig lymphatic leukemia: a "B" cell leukemia.

[Immunotherapeutic studies on EN-L2C guinea pig leukemia].

Effect of various immunomodulators in combination with chemotherapeutic agents were studied using EN-L2C cell line, an acute lymphoblastic leukemia (ALL) of inbred strain-2 guinea pig. Results obtained were followings. 1) Typical leukemic cells appeared in peripheral blood 12 days after the inoculation of 10, cells and the hosts died within 5 days. When EN-L2C cells were inoculated together wit...

Immunogenicity and immunosensitivity of a guinea pig B-cell leukemia subline lacking cell surface Ia antigens.

L2C is a transplantable B-cell leukemia of strain 2 guinea pigs. Transplantation protection experiments were performed with L2C sublines expressing or lacking cell surface antigens coded for by the I region of the major histocompatibility complex (Ia). A subline (BZ-L2C) that lacked cell surface Ia antigens was immunogenic but relatively resistant to immunological attack. The data suggest that ...

Immunogenicity and Immunosensitivity of a Guinea Pig B-Cell Leukemia Subline Lacking Cell Surface la Antigens

L2C is a transplantable B-cell leukemia of strain 2 guinea pigs. Transplantation protection experiments were performed with L2C sublines expressing or lacking cell surface antigens coded for by the I region of the major histocompatibility complex (la). A subline (BZ-L2C) that lacked cell surface la antigens was immunogenic but relatively resistant to immunological attack. The data suggest that ...

Corticosteroid Production Rates in Strain 2 Guinea Pigs following L2C/NB Leukemia Transplantation1

Production rates of cortisol, 2a-hydroxycortisol, and 6/3hydroxycortisol were determined (by isotope dilution technics) in individual adult Strain 2 guinea pigs following transplantation of the guinea pig lymphoblastic leukemia I^C/NB. There was a statistically significant (P < 0.01, 0.02, and 0.01) 2.0-, 1.4-, and 1.9-fold higher production of cortisol, 2a-hydroxycortisol, and 6/3-hydroxycorti...